About FIP

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About

FIP Symptoms

  • Effusive (wet) FIP

When ascites or pleural effusion is found in wet FIP cats under 2 years old, feline infectious peritonitis is highly suspected.

  • Non-effusive (dry)

    Dry FIP usually has a long subclinical period and needs to be observed in combination with clinical symptoms. Symptoms include periodic fever, drowsiness, loss of appetite and weight loss, growth retardation, dry hair, and no response to antibiotics. Blood biochemistry is helpful to the diagnosis of FIP. FCoV titer ≥ 1:3200 can be reasonably inferred as FIP.

  • Transition from non overflow (dry) FIP to overflow (wet) FIP

The two forms of FIP are interchangeable to some extent. When it is observed in experimental infection, the dry type is always accompanied by transient exudative disease. At the end of naturally occurring dry FIP, immunity will completely collapse and the disease will return to a more active form.

Effusive (wet) FIP
Clinical symptoms

213x139 临床症状

1. An enlarged abdomen with ascites evidenced by ultrasound or X-ray.
2. Breathing is getting faster and faster, and ultrasound or X-ray shows pleural effusion.
3. Ascites with pleural effusion.
The usual symptoms are one of the three above.
1. Anorexia, fatigue, lethargy
2. Weight loss
1. Periodic fever lasting more than 4 days (> 102.5°F)
2. High titer of coronavirus
3. Non-regenerative anemia
4. Absolute neutrophil increase
5. Absolute lymphopenia
6.ALB decreases, GLOB increases, A:G ≤ 6
7. Jaundice, elevated TBIL, etc.
Body fluid analysis (ascites, pleural effusion)
yellow ☑ yellow-green ☑ light yellow ☑ dark yellow ☑ milky white × blood red ×
Rivalta Test: Positive
Ascites, pleural effusion.
RTPCR : positive
Ascites, pleural effusion, cerebrospinal fluid, feces, serum/plasma, etc. 
* When the Rivalta test result is negative, the possibility of FIP can be reasonably excluded. However, reading tests are subjective, so the results are somewhat up to the rater.
RT-PCR is a commonly used diagnostic test with approximately 30% false-negative results. A positive test result is highly indicative of the presence of FIPV, and a negative result cannot be used to rule out disease, especially when only serum, plasma, and stool samples are available. 
While many cats with FIP have characteristic CBCs, albumin and globulin levels, and A:G, not every cat will fully meet the above parameters, which still need to be considered in conjunction with age, origin, clinical signs, and physical examination. The results are considered comprehensively. If these common abnormalities are broadly consistent with clinical symptoms, the diagnosis of feline infectious peritonitis is reasonable.

Clinical symptoms

Non-effusive (dry) FIP Clinical symptoms

213x139.2 临床症状

1. Anorexia, fatigue, lethargy,
2. to lose weight,
3. Periodic fever lasting more than 4 days. (102.5°F),
4. Non-regenerative anemia,
5. Absolute neutrophil increase,
6. Absolute lymphopenia,
7. TP increases, GLOB increases, ALB decreases, A:G≤6,
8. High titer of coronavirus,
9. Persistent extensive mesenteric lymphadenopathy,
10. Multiorgan inflammatory granuloma,
11. Mild ascites around abdominal organs,
12. Jaundice, increased TBIL, etc.
13. Eye lesions (uveitis)
14. Nervous system sign lesions (clinically characterized by resting tremor, hind limb weakness, rigidity, bradykinesia, and postural instability. Confusion, incontinence, seizures, convulsions, paralysis, disorientation may occur in advanced stages and shock).
While many cats with FIP have characteristic CBCs, albumin and globulin levels, and A:G, not every cat will fully meet the above parameters, which still need to be considered in conjunction with age, origin, clinical signs, and physical examination. The results are considered comprehensively. If these common abnormalities are broadly consistent with clinical symptoms, the diagnosis of feline infectious peritonitis is reasonable.

Effusive (wet) FIP Infection Stage

Early

Kittens (≤ 2 years old) have periodic fever, drowsiness, loss of appetite, weight loss, growth retardation, dry hair and ineffective antibiotic treatment, so FIP needs to be questioned. Some FIP cases may also have clinical symptoms of diarrhea or constipation.
FIP usually leads to leukocytosis, neutropenia, lymphopenia, elevated serum total protein, hyperglobulinemia and hypoalbuminemia, a: G ≤ 0.6.
Wet FIP usually has ascites or pleural effusion. The increase of ascites will lead to the gradual enlargement of the abdomen and softer touch. When you gently tap its abdomen, the water waves will flicker, and the increase of pleural effusion will also lead to faster breathing. Pleural effusion can be drained, but ascites should not be drained unless it affects breathing.

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Interim

With the development of the disease, the above symptoms will gradually worsen. Or cause chronic non regenerative anemia (HCT ≤ 24%) and hyperbilirubinemia, and the urine is golden yellow to dark yellow; The increase of ascites or pleural effusion may lead to dyspnea. When the cat starts abdominal breathing, it needs to be sent to hospital in time; At the same time, the appetite will further decline and can only eat a small amount of food.

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Late

As the virus destroys and damages the function of immune cells, the disease worsens. Infected cats will have other signs and symptoms, such as severe anemia (HCT ≤ 16%), when HCT ≤ 14%), blood transfusion is recommended in time. Loss of self eating ability, unstable walking, ataxia, and severe jaundice anemia and hemolytic anemia. The median survival time of wet FIP is only 8 days, so early diagnosis is very important, and the treatment of wet FIP is relatively easy. Through timely treatment, the clinical symptoms are reversible, and the quality of life can be completely restored to a healthy level. However, in the late stage of wet FIP, irreversible damage such as multiple organ failure may occur. At this stage, about 50% of cats may still die within 1 to 7 days after treatment.

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Success Rate

2 - 2 days

Significant improvement

1 days

Cure Guarantee

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Overcome FIP

Effusive (wet) FIP more

Pericardial effusion

FIP fibrous pericarditis may be accompanied by pericardial effusion with or without other exudates. According to a survey, FIP is the second most common cause…

Peritoneal effusion (peritonitis)

Exudative FIP accumulates in the abdominal cavity, resulting in progressive and painless fluid increase in the abdominal cavity. diagnose abdominal exudate by palpation and percussion…

Pleural effusion (pleurisy)

Shortness of breath and exercise intolerance are the main clinical manifestations. This is because pleural effusion causes compression and limits the expansion of the lungs.…

Non-effusive (dry) FIP More

Lung disease

Suppurative granulomatous pneumonia can be found in chest radiography or autopsy of FIP cats, but most cases have no clinical symptoms or only cause mild…

Nervous system

Inflammatory injury occurs around blood vessels, usually including meninges and ependymal layers. A report shows that 29% of FIP cats have neurological symptoms. A retrospective…

Eye diseases

FIP eye injury is usually bilateral, involving vascular membrane or uveitis (uveitis). Injuries sometimes lead to blindness. the manifestations of exudative anterior uveitis (iridocyclitis) may…

Liver disease

1 . Symptoms of liver failure and pyogenic hepatitis (FIP). The most common laboratory abnormalities are bilirubinuria and hyperbilirubinemia. Serum liver enzyme activity and bile…

Kidney disease

Pyogenic granulomatous nephritis makes the kidney swollen, hard and unsmooth (uneven) by palpation. Pyogenic granuloma is distributed on the surface of the kidney or infiltrates…

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